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Acanthamoeba keratitis

MedGen UID:
1268
•Concept ID:
C0000880
•
Disease or Syndrome
Synonyms: Acanthamoeba Keratitides; Acanthamoeba Keratitis; Keratitides, Acanthamoeba; Keratitis, Acanthamoeba
SNOMED CT: Acanthamoeba keratitis (231896005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005629
Orphanet: ORPHA67043

Definition

A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcanthamoeba keratitis
Follow this link to review classifications for Acanthamoeba keratitis in Orphanet.

Professional guidelines

PubMed

Steroids in the Management of Infectious Keratitis.
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Recent clinical studies

Etiology

Contact Lens-Related Corneal Infections.
Linaburg TJ, Hammersmith KM
Infect Dis Clin North Am 2024 Dec;38(4):795-811. Epub 2024 Sep 12 doi: 10.1016/j.idc.2024.07.010. PMID: 39271302
The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1.
Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
The biology of Acanthamoeba keratitis.
Niederkorn JY
Exp Eye Res 2021 Jan;202:108365. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108365. PMID: 33221372Free PMC Article
Acanthamoeba keratitis.
Ishibashi Y
Ophthalmologica 1997;211 Suppl 1:39-44. doi: 10.1159/000310885. PMID: 9065937

Diagnosis

The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1.
Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Infectious keratitis: A review.
Cabrera-Aguas M, Khoo P, Watson SL
Clin Exp Ophthalmol 2022 Jul;50(5):543-562. Epub 2022 Jun 3 doi: 10.1111/ceo.14113. PMID: 35610943Free PMC Article
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Acanthamoeba Keratitis.
Fu L, Gomaa A
N Engl J Med 2019 Jul 18;381(3):274. doi: 10.1056/NEJMicm1817678. PMID: 31314971
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Therapy

The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1.
Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Steroids in the Management of Infectious Keratitis.
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Prognosis

The global epidemiology and clinical diagnosis of Acanthamoeba keratitis.
Zhang Y, Xu X, Wei Z, Cao K, Zhang Z, Liang Q
J Infect Public Health 2023 Jun;16(6):841-852. Epub 2023 Mar 23 doi: 10.1016/j.jiph.2023.03.020. PMID: 37030037
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
The biology of Acanthamoeba keratitis.
Niederkorn JY
Exp Eye Res 2021 Jan;202:108365. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108365. PMID: 33221372Free PMC Article
Acanthamoeba keratitis.
Graffi S, Peretz A, Jabaly H, Naftali M
Isr Med Assoc J 2013 Apr;15(4):182-5. PMID: 23781754
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Clinical prediction guides

Clinical outcomes and prognostic factors in Acanthamoeba keratitis.
Vilares-Morgado R, Ferreira AM, Marques-Couto P, Madeira C, Moreira R, Torrão L, Neves-Cardoso P, Cunha AM, Rebelo S, Pinheiro-Costa J
Cont Lens Anterior Eye 2024 Apr;47(2):102119. Epub 2024 Jan 13 doi: 10.1016/j.clae.2023.102119. PMID: 38220498
Steroids in the Management of Infectious Keratitis.
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Diagnosis and treatment of Acanthamoeba Keratitis: A scoping review demonstrating unfavorable outcomes.
Büchele MLC, Nunes BF, Filippin-Monteiro FB, Caumo KS
Cont Lens Anterior Eye 2023 Aug;46(4):101844. Epub 2023 Apr 26 doi: 10.1016/j.clae.2023.101844. PMID: 37117130
Acanthamoeba Keratitis: Perspectives for Patients.
Bonini S, Di Zazzo A, Varacalli G, Coassin M
Curr Eye Res 2021 Jun;46(6):771-776. Epub 2020 Nov 29 doi: 10.1080/02713683.2020.1846753. PMID: 33151784
Medical interventions for acanthamoeba keratitis.
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article

Recent systematic reviews

Diagnostic accuracy of confocal scan in detecting acanthamoeba keratitis and fungal keratitis: a systematic review and meta-analysis.
Moshtaghion SM, Abolhosseini M, Yaseri M, Hosseini SB, Kanavi MR
Int Ophthalmol 2023 Aug;43(8):3011-3022. Epub 2023 Mar 28 doi: 10.1007/s10792-023-02689-z. PMID: 36977847
Genotype distribution of Acanthamoeba in keratitis: a systematic review.
Diehl MLN, Paes J, Rott MB
Parasitol Res 2021 Sep;120(9):3051-3063. Epub 2021 Aug 5 doi: 10.1007/s00436-021-07261-1. PMID: 34351492Free PMC Article
Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.
Ting DSJ, Henein C, Said DG, Dua HS
Sci Rep 2021 Jun 21;11(1):13007. doi: 10.1038/s41598-021-92366-x. PMID: 34155280Free PMC Article
Medical interventions for acanthamoeba keratitis.
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article
New approach to diagnosis and treatment of Acanthamoeba keratitis--systematic review of literature.
Kokot J, Dobrowolski D, Lyssek-Boroń A, Milka M, Smedowski A, Wójcik Ł, Wowra B, Wyligała E
Klin Oczna 2012;114(4):311-6. PMID: 23461162

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